ABSTRACT
Peripheral inflammation flares up the ongoing damage within the central nervous system with neurodegenerative disease, such as Parkinson's disease, Alzheimer's disease, and multiple sclerosis. Therefore, systemic inflammation is considered a key feature in aggravation and evolution of the neurodegenerative diseases. Pro-inflammatory cytokines induce the synthesis of cytokines within the brain, being responsible of both pathological and behavioural changes. Recently, the coronavirus disease-2019, induced by the infection of the SARS-CoV-2, characterized by the peripheral “cytokine storm”, is associated to neurological disorders. In the present article we will summarize the main aspects related to the relationship between periphery and brain and its associated mechanisms.